The Science
Transforming life through groundbreaking research and development
Why MS OCCURS
MS is an autoimmune disease that damages the myelin coating around nerve fibres, causing disruption of nerve signals
This disruption can cause problems with vision, movement, strength, coordination and thinking
In a healthy neuron, myelin protects nerve fibres, like insulation around a wire
Patients with MS exhibit damaged myelin and nerve fibres (demyelination)
There is no cure for MS
Most of current disease-modifying therapies (DMTs) target the immune system
They aim of reduce the frequency and severity of relapses and speed recovery post-relapse in non-progressive forms of the disease
There are 19 drugs approved by the FDA…
…none stop or reverse
the course of MS
None of the drugs seek to repair or reverse the damage of myelin, (remyelination),which may stop progression reverse the course of MS
Effective in Animal Models
Mouse model shows remarkable improvement after treatment with DioprotectomeTM for 15 days
Day 15: The mouse exhibits MS symptoms (tail and hind limb paralysis) and was unable to walk properly
Full video is available in data room or can be accessed by scanning the QR code
Day 30 during the MS-like disease course (15 days after daily oral treatment with DioprotectomeTM): The mouse’s tail and hind-limb functions were restored and showed significant improvement in walking
Demonstrated Remyelination
Low Magnification
High Magnification
Loss of coating around nerve cells with degeneration
(demyelination/loss of myelin & axons)
Dioprotectrome™ treated
Repair of coating around nerve fibres
(remyelination) and neurological recovery
Repair of coating around nerve fibres(remyelination) and neurological recovery
Grants and Partnerships
Grants
NeuOrphan has received research grants of approx. AUD4M secured through competitive grant schemes from the following organisations:
Significant Partnerships
NeuOrphan has partnerships with leading research facilities that accelerates the progress of commercialisation:
Selection of Research
Overcoming Monocarboxylate Transporter 8 (MCT8)
Thyroid Hormone Signaling in Oligodendrocytes
The iron maiden: Oligodendroglial metabolic dysfunction
Oligodendroglial Lineage Cells in Thyroid Hormone-Deprived Conditions
